Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44 Page 45 Page 46 Page 47 Page 48 Page 49 Page 50 Page 51 Page 52 Page 53 Page 54 Page 55 Page 56 Page 57 Page 58 Page 59 Page 60 Page 61 Page 62 Page 63 Page 64 Page 65 Page 66 Page 67 Page 68 Page 69 Page 70 Page 71 Page 72 Page 73 Page 74 Page 75 Page 76 Page 77 Page 78 Page 79 Page 80 Page 81 Page 82 Page 83 Page 84 Page 85 Page 86 Page 87 Page 88 Page 89 Page 90 Page 91 Page 92 Page 93 Page 94 Page 95 Page 96 Page 97 Page 98 Page 99 Page 100 Page 101 Page 102 Page 103 Page 104 Page 105 Page 106 Page 107 Page 108INTRODUCTION 11 In 2009, funding from the American Recovery and Reinvestment Act created the opportunity for the HRS to make its case for creating a genetic resource for research. Awarded multi-year RC2 and RC4 awards (National Institutes of Health Director’s Opportunity Award), the HRS has genotyped nearly 20,000 participants using state-of-the-art technology. With over 180 approved studies in the National Institutes of Health database of genotypes and phenotypes (dbGaP), and participation in dozens of consortia projects, the HRS is now among the most influential genetic cohorts, and by far the most impactful social science survey in the study of human genetics. Psychosocial and Lifestyle Factors Compared to the first 30 years of life, scientists know relatively little about how we change and grow in later life. Many people can now expect to live a long life, and to understand more about what influences vitality, well-being, and life quality during these added years, the HRS also measures psychosocial functioning. As part of the EFTF interview, participants are given a self-administered questionnaire that asks about participants’ well-being, various sources of stress, social relationships, personality and beliefs, and experiences at work (Figure A-2). FIGURE A-2  HRS psychosocial content: 2010 and beyond Well-being Lifestyle Social Relationships Life satisfaction Domain satisfaction Depression Positive/negative affect Hedonic well-being Purpose in life Personal growth Financial strain Activities in life Neighborhood evaluation Religiosity Discrimination Lifetime traumas Early life experiences Stressful life events Ongoing stress Spouse/child/kin/friends Positive support Negative support Closeness Loneliness Early parental relationships Friend contact Child contact Personality Work Self-related Beliefs Extraversion Neuroticism Openness Agreeableness Conscientiousness Cynical hostility Anxiety Anger Work stress Work discrimination Work satisfaction Capacity to work Effort-reward balance Work support Work/family priorities Work/life balance Personal mastery Perceived constraints Hopelessness Subjective age Perceptions of aging Subjective social status Optimism Pessimism