Exonic variants have been measured using the Illumina Human Exome BeadChip v1 on the approximately 15,500 samples collected from 2006 through 2010. These exome data are available through HRS and dbGaP. These exonic variants are also being measured on the 2012 samples using the Illumina HumanOmni2.5 plus Exome array. For more information on the data collection, genotyping, and annotation of these data pleas refer to the Quality Control Report for Exome Chip Data.
How to Apply
The genotype data and a limited set of phenotype measures have been deposited in the NIH GWAS repository (dbGaP), which provides a convenient method of distribution to researchers who meet NIH requirements for access. Researchers wishing to use the HRS genetic data must first apply to dbGaP for access to the genotyped data. The process to request access to any dbGaP study is done via the dbGaP authorized access system. Please see the YouTube video dbGaP: Apply for Controlled Access Data for a step-by-step demonstration of how the process works.
Once access to dbGaP has been granted, researchers who wish to link to HRS phenotype measures not in dbGaP may apply for access to the HRS-dbGaP Cross-Reference File by submitting a Genetic Data Access Use Agreement.
HRS Public Data
Restricted Data Linkages
Users wishing to link to HRS restricted data products must submit a restricted data application.