Home » Genetics
With financial support from the National Institute of Health's (NIH) Director's Opportunity for Research awards using American Reinvestment and Recovery Act funds (RC2 AG036495-01, RC4 AG039029-01), the HRS has genotyped almost 20,000 respondents who provided DNA samples and signed consent forms in 2006-2012.
Several genetic data products derived from these samples are available. Some data are distributed through the NIH GWAS repository (dbGaP) and others are HRS data products. Detailed information can be found on each product's page.
Important note concerning flipped strand issues and associated correction method
In mid-2014, we became aware of an annotation issue with the Illumina HumanOmni2.5-v1_D manifest that caused strand flip errors in the annotation for approximately 20,000 SNPs genotyped in the Health and Retirement Study 2006/2008 samples. This manifest also served as the foundation for the 1000 Genomes imputation for those samples. We systematically investigated the problem and identified two issues with the Illumina HumanOmni2.5-v1_D manifest that led to the strand flip errors. The issues are described in detail in HRS1-2_dbGaPUserInfo_v3.pdf
In order to correct the flipped strand issue, users should take the following action. SNPs that are affected by the strand swap are flagged as problem.type2.SNP = TRUE in HRS1-2_HumanOnmi2.5v1_D_flaggedSNPs.zip. Users should switch the coded and non-coded allele annotation for the affected SNPs in the annotation files. For example, if coded_allele=A and noncoded_allele=T, then coded_allele should be T and noncoded _allele should be A.